3-Hydroxy-Tetrahydrofuran (THF) Pharmaceutical Intermediates High Purity for Synthesis
Product Name: 3-Hydroxy-Tetrahydrofuran (THF)
CAS Number: 453-20-3
Molecular Formula: C4H8O2
Purity: ≥97% (GC)
Appearance: Colorless, viscous liquid
Packaging: Available in 25 kg, 50 kg, or 200 kg plastic drums, or customized packaging upon request.
3-Hydroxy-Tetrahydrofuran (THF) is an essential pharmaceutical intermediate and a key reagent in organic synthesis. With a purity of ≥97%, it is a colorless, viscous liquid commonly used in the production of pharmaceutical compounds, bioactive molecules, and polymeric materials. The compound features a hydroxyl group (-OH) attached to the tetrahydrofuran ring, imparting unique reactivity, which makes it valuable in the synthesis of complex chemical intermediates.
This intermediate plays a pivotal role in medicinal chemistry, polymer chemistry, and organic synthesis, serving as a building block for a variety of advanced chemical reactions.
| Property | Specification |
|---|---|
| Appearance | Colorless viscous liquid |
| Purity (GC) | ≥97.0% |
| CAS Number | 453-20-3 |
| Molecular Formula | C4H8O2 |
| Boiling Point | 215°C |
| Melting Point | -49°C |
| Solubility | Soluble in water, ethanol, and other polar solvents |
| Odor | Slight chemical odor |
Pharmaceutical Synthesis:
3-Hydroxy-Tetrahydrofuran is used as a precursor in the synthesis of pharmaceutical intermediates for various therapeutic areas, including antiviral, anticancer, and anti-inflammatory drugs. Its structural versatility enables the creation of complex bioactive molecules.
Polymer Chemistry:
The compound is a key ingredient in the production of high-performance polymers, including polyurethanes and epoxy resins. It is used as a chain extender or crosslinking agent in adhesives, coatings, and plastics.
Organic Synthesis:
In organic chemistry, it serves as an intermediate for the synthesis of various organic compounds. The hydroxyl group allows it to participate in nucleophilic substitution reactions, esterifications, and other chemical transformations.
Medicinal Chemistry:
3-Hydroxy-Tetrahydrofuran is also being explored for its potential biological activities and use as a drug precursor. It is particularly valuable in the synthesis of novel pyrrole and furan derivatives.
Storage Conditions:
Store in a cool, dry place, away from heat, moisture, and direct sunlight. Seal containers tightly when not in use to avoid contamination.
Shelf Life:
The compound has a shelf life of 2 years when stored properly in its original packaging.
Handling:
When handling larger quantities, use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Ensure adequate ventilation in work areas.
Safety:
3-Hydroxy-Tetrahydrofuran is considered to have low toxicity, but direct contact with skin or eyes may cause irritation. Follow standard safety protocols, including the use of gloves and goggles during handling.
Environmental Impact:
Under normal conditions, this compound is not hazardous to the environment. However, spills should be avoided, and disposal must comply with local environmental regulations.
