3-Hydroxy-Tetrahydrofuran (THF) Pharmaceutical Intermediates High Purity for Synthesis
Product Name: 3-Hydroxy-Tetrahydrofuran (THF)
CAS Number: 453-20-3
Molecular Formula: C4H8O2
Purity: ≥97% (GC)
Appearance: Colorless viscous liquid
Packaging: Available in 25 kg, 50 kg, or 200 kg plastic drums or customized packaging options upon request.
3-Hydroxy-Tetrahydrofuran (THF) is a specialized pharmaceutical intermediate that plays a crucial role in organic synthesis and the development of bioactive compounds. With a purity of ≥97%, it is a colorless, viscous liquid commonly used in the synthesis of various pharmaceutical compounds, biological molecules, and polymeric materials.
This compound features a hydroxyl group (-OH) attached to the tetrahydrofuran ring, providing it with unique reactivity and making it an essential building block in the synthesis of advanced chemical intermediates. The product is also utilized in medicinal chemistry, polymerization reactions, and specialty chemical applications.
| Property | Specification |
|---|---|
| Appearance | Colorless viscous liquid |
| Purity (GC) | ≥97.0% |
| CAS Number | 453-20-3 |
| Molecular Formula | C4H8O2 |
| Boiling Point | 215°C |
| Melting Point | -49°C |
| Solubility | Soluble in water, ethanol, and other polar solvents |
| Odor | Characteristic, slight chemical odor |
Pharmaceutical Synthesis: 3-Hydroxy-Tetrahydrofuran is used as a building block in the synthesis of pharmaceutical intermediates for various therapeutic areas such as antiviral, anticancer, and anti-inflammatory drugs. The compound's unique structure enables modular functionalization, facilitating the creation of complex bioactive molecules.
Polymer Chemistry: This compound is essential for the synthesis of polymeric materials, including polyurethanes and epoxy resins, where it can act as a chain extender or crosslinking agent. It is widely used in the manufacture of high-performance materials for applications in adhesives, coatings, and plastics.
Organic Synthesis: 3-Hydroxy-THF is used as an intermediate in the preparation of a range of organic compounds. Its hydroxyl group makes it suitable for nucleophilic substitution reactions, esterifications, and other chemical transformations.
Medicinal Chemistry: The compound is studied for its biological properties and potential use as a drug precursor or intermediate in various drug development processes, particularly in the synthesis of novel hydroxylated pyrrole and furan derivatives.
Storage Conditions: Store in a cool, dry place, away from heat, moisture, and direct sunlight. Keep containers tightly sealed when not in use to avoid contamination.
Shelf Life: The compound has a shelf life of 2 years when stored properly in its original container.
Handling: Use appropriate personal protective equipment (PPE), including gloves, goggles, and lab coats. Always ensure proper ventilation when handling larger quantities of this compound.
Safety: 3-Hydroxy-Tetrahydrofuran is considered to have low toxicity but should still be handled with care. Direct contact with skin or eyes may cause irritation. It is advisable to follow standard laboratory safety protocols, including wearing protective gloves and goggles when handling the substance.
Environmental Impact: The compound is not considered hazardous to the environment under normal conditions. However, spillage should be avoided, and appropriate disposal methods should be followed according to local environmental regulations.
